Dr. DeKosky is Professor and Chair of the Department of Neurology, and Director of the Alzheimer’s Disease Research Center (ADRC) at the University of Pittsburgh. His clinical research includes differential diagnosis, neuroimaging, and genetic risks of Alzheimer’s disease and other dementias of late life, and trials of new medications. His basic research centers on structural and neurochemical changes in human brains in normal aging and dementia. He is director of a national multicenter trial to assess whether Ginkgo biloba can delay onset of dementia in normal elderly adults. Dr. DeKosky is also Director of the Pittsburgh Institute for Neurodegenerative Diseases (PIND), an interdisciplinary institute for clinical and basic research in neurodegenerative diseases of late life, especially Parkinson’s, Alzheimer’s and amyotrophic lateral sclerosis (ALS; Lou Gehrig’s Disease).
Dr. DeKosky has served as Chair of the Section on Geriatrics of the American Academy of Neurology (AAN). He chaired the recent AAN Practice Parameters Committee for Early Detection, Diagnosis and Management of Dementia. He has been an Examiner in Neurology for the American Board of Psychiatry and Neurology (ABPN) for over 15 years and served as a member of the ABPN Part I (Written) Examination Committee for 10 years. In 2002 he was elected to the Neurology Council of the ABPN; he is one of the eight neurologists who oversee board certification in the U.S. He has received a Teacher Investigator Development Award from the NINDS, the Presidential Award of the American Neurological Association, and is listed in "The Best Doctors in America." He has published over 200 peer-reviewed articles and book chapters.
Research Areas of Interest: Alzheimer's disease
Pathology and pathways of Alzheimer's disease with an update on new
developments in treatment.
J Am Geriatr Soc. 2003 May;51(5 Suppl Dementia):S314-20. Review.
PMID: 12801388 [PubMed - indexed for MEDLINE]
Lyketsos CG, Lopez O, Jones B, Fitzpatrick AL, Breitner J, DeKosky S.
Prevalence of neuropsychiatric symptoms in dementia and mild cognitive
impairment: results from the cardiovascular health study.
JAMA. 2002 Sep 25;288(12):1475-83.
PMID: 12243634 [PubMed - indexed for MEDLINE]
Nebes RD, Reynolds CF 3rd, Boada F, Meltzer CC, Fukui MB, Saxton J, Halligan
EM, DeKosky ST.
Longitudinal increase in the volume of white matter hyperintensities in
Int J Geriatr Psychiatry. 2002 Jun;17(6):526-30.
PMID: 12112176 [PubMed - indexed for MEDLINE]
Lopez OL, Becker JT, Wisniewski S, Saxton J, Kaufer DI, DeKosky ST.
Cholinesterase inhibitor treatment alters the natural history of Alzheimer's
J Neurol Neurosurg Psychiatry. 2002 Mar;72(3):310-4.
PMID: 11861686 [PubMed - indexed for MEDLINE]
DeKosky ST, Ikonomovic MD, Styren SD, Beckett L, Wisniewski S, Bennett DA,
Cochran EJ, Kordower JH, Mufson EJ.
Upregulation of choline acetyltransferase activity in hippocampus and frontal
cortex of elderly subjects with mild cognitive impairment.
Ann Neurol. 2002 Feb;51(2):145-55.
PMID: 11835370 [PubMed - indexed for MEDLINE]